Southern Pacific No. 4426 may refer to:
- Southern Pacific No. 4426 (Steam) - A Southern Pacific Class GS-3 locomotive built by the Lima Locomotive Works in 1937 for the Southern Pacific Railroad and was scrapped.
- Southern Pacific No. 4426 (Diesel) - An EMD SD9 locomotive built by the Electro-Motive Division for the Southern Pacific Railroad and is currently in preservation.