Southern Pacific No. 4418 may refer to:
- Southern Pacific No. 4418 (Steam) - A Southern Pacific Class GS-3 steam locomotive built in 1937 by the Lima Locomotive Works for the Southern Pacific Railroad.
- Southern Pacific No. 4418 (Diesel) - An EMD SD9 diesel locomotive built in 1955 by the Electro-Motive Division for the Southern Pacific Railroad.