Southern Pacific No. 4412 may refer to:
- Southern Pacific No. 4412 (Steam) - A Southern Pacific Class GS-2 built by the Lima Locomotive Works in 1936 for the Southern Pacific Railroad, which got scrapped in 1956.
- Southern Pacific No. 4412 (Diesel) - An EMD SD9 that was built by the Electro-Motive Division in 1954 for the Southern Pacific Railroad and its current whereabouts are unknown.