Southern Pacific No. 4404 may refer to:
- Southern Pacific No. 4404 (Steam) - A Southern Pacific Class GS-1 steam locomotive built by the Baldwin Locomotive Works for the Southern Pacific Railroad in June 1930, retired from service and scrapped.
- Southern Pacific No. 4404 (Diesel) - An EMD SD9 diesel locomotive built by the Electro-Motive Division for the Southern Pacific Railroad and is currently in preservation.