Great Western Railway may refer to the following:
Argentina[]
- Argentine Great Western Railway - a railway in Argentina
Australia[]
- Great Western Railway (Queensland), Australia - A railway in Queensland, Australia.
- Great Western Railway (Tasmania), Australia - A proposed and never built railway in Tasmania, Australia.
Brazil[]
- Great Western Railway of Brazil - A railway in Brazil.
Canada[]
- Great Western Railway (Ontario)
- Great Western Railway (Saskatchewan)
Ireland[]
- Midland Great Western Railway - A railway in Ireland.
United Kingdom[]
- Great Western Railway (original) - A railway company as part of the big four railways in the UK.
- Great Western Railway (1996) - A train operating company from 1996.
- Great Western Main Line - A main line railway in England, from London Paddington to Bristol Temple Meads.
United States[]
- Atlantic and Great Western Railroad (1853–1880).
- Chicago Great Western Railway (1885–1968) - A railway in Chicago, Illinois.
- Great Western Railway of Colorado - A railway in Colorado.
- Great Western Railroad (Illinois) (1853–65)
- Great Western Railway of Iowa - A railway in Iowa.
- Great Western Railroad (Ohio) - A railway in Ohio.
- New Orleans, Opelousas and Great Western Railroad (1854–1869), A railroad that would eventually became part of the Southern Pacific Company.